Table 1 Summary of selected reactions carried out in this study
Reaction | Thioamide produced | Conditions used | Notes |
|---|---|---|---|
Reducing sulfidic spark discharge mixture + \(\hbox {CH}_{3}\hbox {SH}\) | Thioformamide | Incubation reaction carried out at RT | See text for spark discharge description |
Neutral sulfidic spark discharge mixture + \(\hbox {CH}_{3}\hbox {SH}\) | Thioformamide | Incubation reaction carried out at RT | See text for spark discharge description |
HCN + \(\hbox {H}_{2}\hbox {S}\) + \(\hbox {CH}_{3}\hbox {SH}\) | Thioformamide | pH 7 and 11; 4\(^\circ\)C and RT | Yield of 33% in 48 hours at RT |
HCN + \(\hbox {H}_{2}\hbox {S}\)(g) + \(\hbox {CH}_{3}\hbox {SH}\) | Thioformamide | pH 7; RT | – |
HCN + \(\hbox {H}_{2}\hbox {S}\) + \(\hbox {CH}_{3}\hbox {CH}_{2}\hbox {SH}\) | Thioformamide | pH 7 and 11; RT | – |
HCN + \(\hbox {H}_{2}\hbox {S}\) + cysteamine | None | pH 7; RT | – |
HCN + \(\hbox {H}_{2}\hbox {S}\) + N-acetyl cysteamine | None | pH 7; RT | – |
HCN + \(\hbox {H}_{2}\hbox {S}\) | None | pH 7 and 11; 4\(^\circ\)C and RT | – |
HCN + \(\hbox {H}_{2}\hbox {S}\) + imidazole | None | pH 7; RT | – |
3-cyanopyridine + \(\hbox {H}_{2}\hbox {S}\) + \(\hbox {CH}_{3}\hbox {SH}\) | Thionicotinamide | pH 7; 72 hours at RT | Near complete conversion |
3-cyanopyridine + \(\hbox {H}_{2}\hbox {S}\) | Thionicotinamide | pH 7; 72 hours at RT | Some product observed, but not as much as with thiol catalyst |